Clinical Trials

A worldwide quest is under way to find treatments to stop, slow or even prevent Alzheimer’s disease. Some of the most promising research is happening right here in San Diego. Many of the new drugs in development aim to modify the disease process by impacting the many brain changes that Alzheimer’s causes. In addition to investigating experimental drugs, many clinical trials include brain imaging studies and testing of blood or spinal fluid. Researchers hope these techniques will help diagnose Alzheimer’s disease in its earliest stages or even before symptoms appear.

We need your help. Without participation, finding a cure is virtually impossible.

Sign Up To Learn More About Trials

A groundbreaking local initiative that combines  San Diego’s resources in order to accelerate research and drug discovery projects to find a cure.

Click to download a PDF listing or scroll down below to see a current list of trials that are actively looking for participants.

Current Clinical Trials in San Diego

*Sharp Healthcare Clinical Research

  • Early Study: Study for individuals who are at risk of developing Alzheimer’s disease (family history) but currently have no symptoms.
  • ReCOGNITION Study: Investigation of the drug Piromelantine to improve sleep, improve memory and limit the effects of Alzheimer’s.
  • Navigate Study: Study of an investigational drug on the progression of Alzheimer’s.
  • Daybreak Study: Study of an investigational drug on the progression of Alzheimer’s individuals who are asymptomatic and at risk for developing Alzheimer’s dementia.
  • CREAD 2 Study: Study of a monoclonal antibody on the accumulation of amyloid protein in the brain and delay of disease progression in adults with mild Alzheimer’s.
  • Mission Study: Study of an investigational drug on the progression of Alzheimer’s.

For more information call 858-836-8350 or visit

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

*Pacific Research Network

  • Pacific Research Network (PRN) is a clinical research facility that specializes in examining new, investigational medications for the treatment of Alzheimer’s disease. With over 250 clinical research trials completed over the last 35 years, we are still looking for answers. If you or someone you know is interested in participating in a clinical research study or would like a no-cost memory exam, we are currently looking for volunteers for six Alzheimer’s disease trials.

For more information call 619-294-4302 or visit

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

*Excell Research

  • Biogen – Study for individuals with Early Onset Alzheimer’s disease (or individuals suffering from memory problems but without a diagnosis of Alzheimer’s).
  • Eisai – Study is for individuals experiencing mild cognitive impairment, memory problems, and/or trouble with thinking.
  • IntraCellular Technology – Study is for individuals with agitated behaviors due to Alzheimer’s (i.e. verbal outbursts, pacing, repetition, irritable, etc).

For more information call 760-758-2222 or visit

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

Synergy Research Centers

  • Alzheimer’s and Agitation: A study for people with Alzheimer’s who have agitation. Participants can remain on current Alzheimer’s medication and will be given the study medication or placebo for treatment of agitation.
  • Mild-Moderate: A study for the treatment of mild to moderate Alzheimer’s disease.

For more information call 888-619-7272 or visit

The Research Center of Southern California

  • Daybreak Study: Study of an investigational drug on the progression of Alzheimer’s.
  • CREAD Study: Evaluate the effects of investigational drug Crenezumab in people with early to mild Alzheimer’s disease.

For more information call 760-732-0557 or visit

UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center

  • The UC San Diego, Shiley-Marcos Alzheimer’s Disease Research Center (SMARDC) is the only university-based, federally funded, Alzheimer’s disease research center in San Diego. The SMADRC is currently enrolling participants for a variety of studies including those that test investigational medications and diagnostic methods, longterm observational studies without medication and more. Studies are open to adults with a diagnosis of MCI or dementia, have a family history of Alzheimer’s as well as those without any memory problems. The SMARDC also offers no-cost memory screening and quality of life programs to complement our research efforts. Hablamos Español!

For more information call 858-822-4800 or visit

UCSD Department of Psychiatry

  • Alzheimer’s Caregiver Study: This study investigates whether providing caregivers with coping tools will lower physiological markers related to heart disease. All study visits conducted in-home. For more information call 858-534-9479.
  • Mild Cognitive Impairment: This study compares the impact of a walking program, computer-based cognitive training and the combination of the two on memory, cognition and quality of life in adults with MCI.
  • Mild Cognitive Impairment: The purpose of this study is to see if walking and/or computer cognitive training has a benefit on a person’s cognitive (mental) status.

For more information call 858-642-6375.

UCSD Parkinson’s and Other Movement Disorders Center

  • Dementia with Lewy Bodies Consortium: This study develops a collection of samples from individuals diagnosed with Lewy Body Dementia to help promote future research opportunities. Participants will be followed over a period of 5 years to collect detailed information. For adults 40-90 years of age.

For more information, contact Veronica Lopez, Research Coordinator at or call 858-822-5786.

Advanced Neurobehavioral Health

  • Sleep Study: For people with Alzheimer’s disease, Mild Cognitive Impairment, Parkinson’s disease dementia or Dementia with Lewy Bodies, investigating the relationship between sleep disturbances and cognitive decline.
  • Computer Study: A study examining the effectiveness of a computer program to help distinguish between disorders. No medication or long-term follow-up visits.

For more information, call 619-798-6048 or

PCND Neurosciences

  • XanAdu: The purpose of this study is to see if the investigational drug Xanamem will inhibit the conversion of cortisone to cortisol in the hippocampus. For people with MCI or early stage dementia.

For more information, 858-674-1289 or

Sign Up To Learn More About Trials