Clinical Trials

A worldwide quest is under way to find treatments to stop, slow or even prevent Alzheimer’s disease. Some of the most promising research is happening right here in San Diego. Many of the new drugs in development aim to modify the disease process by impacting the many brain changes that Alzheimer’s causes. Current trials in San Diego County range from drug research to studying the impact of sleep on cognitive decline and caregiver stress.

People with Alzheimer’s, caregivers and healthy volunteers are needed today to participate in Alzheimer’s and dementia research. When you join a clinical trial, you have an opportunity to participate in critical research that could change the course of Alzheimer’s disease and improve the lives of all those it affects. By signing up to learn more, Alzheimer’s San Diego will send you the latest information about local studies that could be a good fit for you.

We need your help. Without participation, finding a cure is virtually impossible.

Sign Up To Learn More About Trials

A groundbreaking local initiative that combines San Diego’s resources in order to accelerate research and drug discovery projects to find a cure.

Click to download a PDF listing or scroll down below to see a current list of trials that are actively looking for participants.

Current Clinical Trials in San Diego

*Sharp Healthcare Clinical Research

  • TauRx: The study is investigating the safety and effectiveness of TRx023 on reducing buildup of Tau tangles and slowing of the disease progression in people with Mild Alzheimer’s.

  • Eisai BAN2401-G000-301: Study is for people who have experienced gradual memory changes for at least 6 months and diagnosed with mild cognitive impairment or Alzheimer’s. The study will test the effectiveness of experimental drug BAN2401.

Insurance is not required for study participation. Participants and study partners are compensated for time and travel and transportation can be provided for each study visit.

For more information call 858-836-8350 or visit www.sharp.com/clinicaltrials.

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

*Pacific Research Network

PRN is seeking volunteers with and without memory concerns to participate in different studies. PRN also offers free memory screenings and APOE testing for those 50yrs and older. Studies change frequently, contact them for more information.

  • Genentech GN400040: This study evaluates the potential effectiveness of an investigational drug to see if it has the potential to slow memory loss progression.
  • Alkahest ALK6019-202: Study to evaluate the safety and potential effectiveness of plasma protein fraction infusions in participants with severe Alzheimer’s disease.
  • Eisai BAN2401-G000-301: Study is for individuals experiencing mild cognitive impairment to mild Alzheimer’s disease.
  • Tetra BPN14770-CNS-201: This study evaluates the potential effectiveness of an investigational drug on early disease progression.Generation 2

For more information call 619-294-4302 or visit www.PRNSD.com.

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

*Excell Research

Excell Research is seeking volunteers with mild cognitive impairment (MCI), memory concerns and/or problems with thinking to participate in Alzheimer’s research. Free memory screenings offered at various locations.

  • AgeneBio: A double-blind, placebo-controlled study evaluating the efficacy and safety of AGB101 (low-dose levetiracetam, 220 mg, extended release tablet) on slowing progression of mild cognitive impairment due to Alzheimer’s disease
  • TauRx: A double-blind, placebo-controlled, three-arm, 9-Month, brain imaging and safety and efficacy study of Leuco-methylthioninium bis (hydromethanesulfonate) (LMTM) in people with early Alzheimer’s Disease

For more information call 760-758-2222 or visit www.excellresearch.com.

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

Alzheimer’s Therapeutic Research Institute
(Keck School of Medicine of USC)

  • Alzheimer Prevention Trials (APT) Webstudy: An online cognitive assessment research study aimed at accelerating the enrollment time for clinical trials designed to prevent Alzheimer’s disease. The purpose of the webstudy is to develop a large online group of individuals who may be at higher risk for developing Alzheimer’s dementia, and who may be interested in participating in a prevention trial.

For more information and additional trials, call 858-964-4644 or visit www.keck.usc.edu/atri.

UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center

  • The UC San Diego, Shiley-Marcos Alzheimer’s Disease Research Center (SMARDC) is the only university-based, federally funded, Alzheimer’s disease research center in San Diego. The SMADRC is currently enrolling for a variety of studies that test investigational medications and diagnostic methods, long-term observational studies without medication and more. Studies are open to adults with MCI or dementia, a family history of Alzheimer’s and those without memory problems. Hablamos Español!

For more information call 858-822-4800 or visit www.adrc.ucsd.edu.

UCSD Department of Psychiatry

  • Memantine Sensitivity Study: A study to learn how to predict who will or won’t benefit from memantine. All subjects receive memantine, cognition tests and EEG to measure brain waves. For information call Joyce at 619-471-9455.
  • Caregiver Study: Examining impact of online tools in helping caregivers manage stress. No investigational drugs. For information call 858-534-9479.
  • Pupil (eye) Response Study: Investigation of pupil response as an indicator of Alzheimer’s. Includes memory/thinking tests and MRI scan of brain. No investigational drugs. For information call Stephanie 858-822-5038.

UCSD Parkinson’s and Other Movement Disorders Center

  • Dementia with Lewy Bodies Consortium: This study develops a collection of samples from individuals diagnosed with Lewy Body Dementia to help promote future research opportunities. Participants will be followed over a period of 5 years to collect detailed information. For adults 40-90 years of age.

For more information, contact Veronica Lopez, Research Coordinator at v1lopez@ucsd.edu or call 858-822-5786.

The Research Center of Southern California

  • Tango Study: This study evaluates the safety, dosing and potential effectiveness of an investigational drug to see if it has the potential to slow disease progression.

For more information call 760-732-0557 or visit www.neurocenter.com.

Advanced Neurobehavioral Health

  • Sleep Study: For people with Alzheimer’s disease, Mild Cognitive Impairment, Parkinson’s disease dementia or Dementia with Lewy Bodies, investigating the relationship between sleep disturbances and cognitive decline.
  • Computer Study: A study examining the effectiveness of a computer program to help distinguish between disorders. No medication or long-term follow-up visits.

For more information, call 619-798-6048 or www.anhsocal.com.

Rice University

  • Caregiver Study: The T-SCAN Lab at Rice University is recruiting primary caregivers to
    loved ones with Alzheimer’s disease for a research study looking at emotion
    regulation and coping strategies for caregivers. Participation is 100% online and will
    be compensated. The study is open to primary caregivers who have a smart
    phone.

For more information contact Jenna at jj64@rice.edu or 713-348-8246