Clinical Trials

A worldwide quest is under way to find treatments to stop, slow or even prevent Alzheimer’s disease. Some of the most promising research is happening right here in San Diego. Many of the new drugs in development aim to modify the disease process by impacting the many brain changes that Alzheimer’s causes. In addition to investigating experimental drugs, many clinical trials include brain imaging studies and testing of blood or spinal fluid. Researchers hope these techniques will help diagnose Alzheimer’s disease in its earliest stages or even before symptoms appear.

People with Alzheimer’s, caregivers and healthy volunteers are needed today to participate in Alzheimer’s and dementia research. When you join a clinical trial, you have an opportunity to participate in critical research that could change the course of Alzheimer’s disease and improve the lives of all those it affects. Currently-enrolling trials in San Diego County range from drug research to studying the impact of sleep on cognitive decline and caregiver stress.

We need your help. Without participation, finding a cure is virtually impossible.

Sign Up To Learn More About Trials

A groundbreaking local initiative that combines San Diego’s resources in order to accelerate research and drug discovery projects to find a cure.

Click to download a PDF listing or scroll down below to see a current list of trials that are actively looking for participants.

Current Clinical Trials in San Diego

*Sharp Healthcare Clinical Research

  • MISSION-AD: This study is for individuals with early Alzheimer’s disease or mild cognitive impairment. The study will last for approximately two years and participants will receive either the study drug (elenbecestat) or a placebo. The study is investigating the safety and effectiveness of elenbecestat on symptoms of Alzheimer’s disease.

  • ReCOGNITION: This study is for people currently taking medication to treat mild Alzheimer’s disease. The study will last for six months, and participants will receive one of three doses of either the study drug (Piromelatine) or a placebo. Participants will continue taking their prescribed medication during the study. The study will determine if Piromelatine will improve slow wave sleep and memory, and limit the effects of Alzheimer’s.

  • TauRx: This study is for people who have been diagnosed with mild Alzheimer’s disease and are not currently taking any medications for Alzheimer’s. The study will last for six months and participants will receive either an investigational drug (TRx0237) or a placebo. The study will assess the safety and effectiveness of TRx023 and determine if the investigational drug will reduce the build-up of tau tangles and slow the disease progression.

  • TRAILBLAZER: This study is for people who have experienced gradual memory changes for at least six months. The study will last for approximately two and a half years and participants will receive one study drug (LY3002813) alone, the study drug (LY3002813) in combination with another study drug (LY3202626), or a placebo. The study will evaluate the safety and effectiveness of the investigational drugs and will determine if they will have any effect in reducing the amount beta amyloid plaques.

For more information call 858-836-8350 or visit www.sharp.com/clinicaltrials.

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

*Pacific Research Network

  • Pacific Research Network (PRN) offers daily, free memory screens and APOE testing at their locations in Hillcrest and Rancho Bernardo. PRN is seeking volunteers with and without memory concerns to participate in different studies. Their enrolling studies change frequently, please contact them for more information.
    Tango | Trailblazer | Periscope | Generation 1 | Reverse-SD | Tauriel | ROAD | Generation 2

For more information call 619-294-4302 or visit www.PRNSD.com.

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

*Excell Research

  • Eisai – Study is for individuals experiencing mild cognitive impairment, memory problems, and/or trouble with thinking.
  • IntraCellular Technology – Study is for individuals with agitated behaviors due to Alzheimer’s (i.e. verbal outbursts, pacing, repetition, irritable, etc).

For more information call 760-758-2222 or visit www.excellresearch.com.

* A valued partner who supports the mission, programs and services of Alzheimer’s San Diego.

UC San Diego Shiley-Marcos Alzheimer’s Disease Research Center

  • The UC San Diego, Shiley-Marcos Alzheimer’s Disease Research Center (SMARDC) is the only university-based, federally funded, Alzheimer’s disease research center in San Diego. The SMADRC is currently enrolling for a variety of studies that test investigational medications and diagnostic methods, long-term observational studies without medication and more. Studies are open to adults with MCI or dementia, a family history of Alzheimer’s and those without memory problems. Hablamos Español!

For more information call 858-822-4800 or visit www.adrc.ucsd.edu.

The Research Center of Southern California

  • Tango Study: This study evaluates the safety, dosing and potential effectiveness of an investigational drug to see if it has the potential to slow disease progression.

For more information call 760-732-0557 or visit www.neurocenter.com.

UCSD Department of Psychiatry

  • Alzheimer’s Caregiver Study: This study investigates whether providing caregivers with coping tools will lower physiological markers related to heart disease. All study visits conducted in-home. For more information call 858-534-9479.

For more information call 858-642-6375.

UCSD Parkinson’s and Other Movement Disorders Center

  • Dementia with Lewy Bodies Consortium: This study develops a collection of samples from individuals diagnosed with Lewy Body Dementia to help promote future research opportunities. Participants will be followed over a period of 5 years to collect detailed information. For adults 40-90 years of age.

For more information, contact Veronica Lopez, Research Coordinator at v1lopez@ucsd.edu or call 858-822-5786.

Advanced Neurobehavioral Health

  • Sleep Study: For people with Alzheimer’s disease, Mild Cognitive Impairment, Parkinson’s disease dementia or Dementia with Lewy Bodies, investigating the relationship between sleep disturbances and cognitive decline.
  • Computer Study: A study examining the effectiveness of a computer program to help distinguish between disorders. No medication or long-term follow-up visits.

For more information, call 619-798-6048 or www.anhsocal.com.

PCND Neurosciences

  • XanAdu: The purpose of this study is to see if the investigational drug Xanamem will inhibit the conversion of cortisone to cortisol in the hippocampus. For people with MCI or early stage dementia.

For more information, 858-674-1289 or www.pcndneurology.com.

Alzheimer’s Therapeutic Research Institute
(Keck School of Medicine of USC)

  • Alzheimer Prevention Trials (APT) Webstudy: An online cognitive assessment research study aimed at accelerating the enrollment time for clinical trials designed to prevent Alzheimer’s disease. The purpose of the webstudy is to develop a large online group of individuals who may be at higher risk for developing Alzheimer’s dementia, and who may be interested in participating in a prevention trial.

For more information and additional trials, 800-872-2273 or www.keck.usc.edu/atri.

Synergy Research Centers

  • IntraCellular Technology: This study is for individuals with agitated behaviors due to Alzheimer’s (i.e. verbal outbursts, pacing, repetition, irritation, etc).

For more information, 619-303-6130 or www.synergyresearchcenters.com.

Sign Up To Learn More About Trials